Genetics

Minimap2: pairwise alignment for nucleotide sequences

The mutational constraint spectrum quantified from variation in 141,456 humans

The UK Biobank resource with deep phenotyping and genomic data

Canu: scalable and accurate long-read assembly via adaptive <i>k</i> -mer weighting and repeat separation

Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2’s q2-feature-classifier plugin

The GTEx Consortium atlas of genetic regulatory effects across human tissues

Past, present, and future of CRISPR genome editing technologies

Sequence modeling and design from molecular to genome scale with Evo

Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy

Antibiotic-Free Gene Vectors: A 25-Year Journey to Clinical Trials

Retroviral Vector Technology for Gene Therapy: History, Current Landscape, and Future Prospects

Adaptation of lentiviral vectors for viral gene therapy and their impact on host cell biology